ELISA NME4 anti-

Quantity :50µL Clone Number: Aliases:metastatic inhibition factor NM23H4 antibody; mitochondrial antibody; NDK antibody; NDKM_ antibody; NDP kinase antibody; NDP kinase D antibody; NDP kinase, mitochondrial antibody; NDPK D antibody; NDPKD antibody; nm23 H4 antibody; nm23-H4 antibody; NM23D antibody; NM23H4 antibody; Nm23M4 antibody; NME/NM23 nucleoside diphosphate kinase 4 antibody; NME4 antibody; Non metastatic cells 4 protein expressed in antibody; Non metastatic protein 23, homolog 4 antibody; Nucleoside diphosphate kinase D antibody; Nucleoside diphosphate kinase, mitochondrial antibody; Nucleoside diphosphate kinase, mitochondrial antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00746 Immunogen:Recombinant Nucleoside diphosphate kinase, mitochondrial protein (1-187AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Throµgh the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regµLation of intracellµLar nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration sµggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimµLate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking sµggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NME4 Research Areas:Neuroscience; Cancer; Metabolism; Signal transduction