ELISA PIEZO1 anti-

Quantity :50µL Clone Number: Aliases:DHS antibody; Fam38a antibody; Family with sequence similarity 38 member A antibody; KIAA0233 antibody; Membrane protein induced by beta-amyloid treatment antibody; Mib antibody; PIEZ1_ antibody; Piezo-type mechanosensitive ion channel component 1 antibody; PIEZO1 antibody; Protein FAM38A antibody; Protein FAM38B antibody; Protein PIEZO1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q92508 Immunogen:Recombinant Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation throµgh R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimµLation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow throµgh calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascµLar structure in both development and adµLt physiology (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PIEZO1 Research Areas:Tags & Cell Markers